Caddo Valley is located on Interstate 30, a connector between coast-to-coast Interstates 40 and 20. Other highways in the region include State Highways 128, 26, 51, 7 and 8, as well as U.S. Highway 67. Due to Clark County's centralized location in the United States, fully one-third of the country is just one tank of gas away.

Less than an hour drive from Little Rock, Caddo Valley and DeGray Lake are easily accessible to major infrastructure and facilities to the Arkansas State Capitol. The Bill and Hillary Clinton National Airport provides connections to anywhere in the world. The community is a four-hour drive from Dallas and a three-hour drive from Memphis.